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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM116815'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM116815
PNG
(US8637532, 541)
Show SMILES CCOC(=O)c1cnc(Nc2cccc(CNc3ncnc4c(cccc34)C(N)=O)c2)s1
Show InChI InChI=1S/C22H20N6O3S/c1-2-31-21(30)17-11-25-22(32-17)28-14-6-3-5-13(9-14)10-24-20-16-8-4-7-15(19(23)29)18(16)26-12-27-20/h3-9,11-12H,2,10H2,1H3,(H2,23,29)(H,25,28)(H,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.160n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair