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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'BRD4 BD1 (aa 42-168)' and Ligand = 'BDBM310873'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310873
PNG
(6-methyl-4-(2-oxoindolin-5-yl)-1H-pyrrolo[2,3-c]py...)
Show SMILES Cn1cc(-c2ccc3NC(=O)Cc3c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C16H13N3O2/c1-19-8-12(11-4-5-17-15(11)16(19)21)9-2-3-13-10(6-9)7-14(20)18-13/h2-6,8,17H,7H2,1H3,(H,18,20)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair