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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'BRD4 BD1 (aa 42-168)' and Ligand = 'BDBM310889'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310889
PNG
(4-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N...)
Show SMILES Cn1cc(-c2ccc(cc2)C(=O)Nc2cccnc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H16N4O2/c1-24-12-17(16-8-10-22-18(16)20(24)26)13-4-6-14(7-5-13)19(25)23-15-3-2-9-21-11-15/h2-12,22H,1H3,(H,23,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair