BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'BRD4 BD1 (aa 42-168)' and Ligand = 'BDBM321353'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (human))
BDBM321353
PNG
(6-but-2-enyl-4-(4-tert-butylphenyl)-1H-pyrrolo[2,3...)
Show SMILES CC=CCn1cc(-c2ccc(cc2)C(C)(C)C)c2cc[nH]c2c1=O
Show InChI InChI=1S/C21H24N2O/c1-5-6-13-23-14-18(17-11-12-22-19(17)20(23)24)15-7-9-16(10-8-15)21(2,3)4/h5-12,14,22H,13H2,1-4H3/b6-5+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair