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Found 3 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM16253'
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant memapsin 2More data for this Ligand-Target Pair