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Found 2 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM16758'
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM16758(5-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50:  400nMAssay Description:Binding affinity against Beta-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM16758(5-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50:  400nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed