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Found 5 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50210579'
TargetBeta-secretase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant BACE1 ectodomain (1 to 460 amino acids) assessed as inhibition of proteolytic cleavage of Rhodamine-EVNLDAEFK-Quenche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBeta-secretase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of active BACE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBeta-secretase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant BACE1 using Mca-SEVNLDAEFK-DNP substrate assessed as substrate hydrolysis after 2 hrs by HPLC-FLU analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBeta-secretase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataIC50:  6nMAssay Description:Inhibition of full-domain of BACE1 expressed in HEK393 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBeta-secretase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB