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Found 6 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50303731'
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  70nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  270nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair