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Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM335458'
Target
Beta-secretase 2
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM335458
(8-((3-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...)
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Affinity Data
Ki: 0.410nM
Assay Description:
The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...
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Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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Details
US Patent
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