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Found 3 Enz. Inhib. hit(s) with Target = 'Bile acid receptor' and Ligand = 'BDBM50323523'
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323523(4-((6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol...)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human GST-fused FXR LBD expressed in HEK293 cells coexpressing GAL4-DNA bindig domain and pFRluc by mammalian one-hybrid assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323523(4-((6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol...)
Affinity DataEC50:  101nMAssay Description:Agonist activity at human full length FXR transfected in HEK293 cells coexpressing pTRexDest/pGL2promotor assessed as luciferase activity by direct r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323523(4-((6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol...)
Affinity DataEC50:  162nMAssay Description:Agonist activity at human GST-fused FXR LBD assessed as cofactor peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed