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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)' and Ligand = 'BDBM313799'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1)


(Homo sapiens (Human))
BDBM313799
PNG
(US10167292, Example 43)
Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccccc3)c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN5O/c1-17(19-8-11-21(27)12-9-19)28-26(33)20-10-13-23-24(16-20)31(22-6-4-3-5-7-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m0/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Catalyst Therapeutics Pty Ltd.

US Patent


Assay Description
BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...


US Patent US10167292 (2019)

More data for this
Ligand-Target Pair