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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)' and Ligand = 'BDBM186321'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM186321
PNG
(US9675697, RX-38)
Show SMILES CCc1onc(C)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC
Show InChI InChI=1S/C18H16ClN3O2/c1-4-14-16(9(2)22-24-14)11-7-13-10(8-15(11)23-3)17-12(21-13)5-6-20-18(17)19/h5-8,21H,4H2,1-3H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
2.81E+3 -31.7n/an/an/an/an/an/a25



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair