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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)' and Ligand = 'BDBM333406'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM333406
PNG
(6-(2,4-Difluorophenoxy)-1-methyl-5-(6-methyl-7-oxo...)
Show SMILES Cn1c2cc(Oc3ccc(F)cc3F)c(cc2[nH]c1=O)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C17H16Cl2N4O2S/c18-10-3-1-2-9(4-10)5-20-16-17-21-6-11(23(17)7-13(19)22-16)15-14(25)12(24)8-26-15/h1-4,6-7,12,14-15,24-25H,5,8H2,(H,20,22)/t12-,14-,15+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair