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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)' and Ligand = 'BDBM333425'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM333425
PNG
(4-[5-(Cyclobutylmethoxy)-2-cyclopentyl-1H-benzimid...)
Show SMILES Cn1cc(-c2cc3[nH]c(nc3cc2OCC2CCC2)C2CCCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H20FN5O2/c19-12-3-1-11(2-4-12)7-8-20-16-18-23-22-17(24(18)10-9-21-16)13-5-6-14(25)15(13)26/h1-4,9-10,13-15,25-26H,5-8H2,(H,20,21)/t13-,14-,15+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair