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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)' and Ligand = 'BDBM333407'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))
BDBM333407
PNG
(4-[6-(2,4-Difluorophenoxy)-1-methyl-1H-benzimidazo...)
Show SMILES Cn1cnc2cc(c(Oc3ccc(F)cc3F)cc12)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C17H17ClN4O2S/c18-11-4-1-3-10(7-11)8-19-12-5-2-6-22-16(12)20-21-17(22)15-14(24)13(23)9-25-15/h1-7,13-15,19,23-24H,8-9H2/t13-,14-,15-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair