BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)' and Ligand = 'BDBM333416'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))
BDBM333416
PNG
(4-[5-(Cyclobutylmethoxy)-1-ethyl-1H-benzimidazol-6...)
Show SMILES CCn1cnc2cc(OCC3CCC3)c(cc12)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H21FN4O2/c20-13-3-1-2-12(10-13)6-7-21-18-19-23-11-15(24(19)9-8-22-18)14-4-5-16(25)17(14)26/h1-3,8-11,14,16-17,25-26H,4-7H2,(H,21,22)/t14-,16+,17-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2)


(Homo sapiens (Human))
BDBM333416
PNG
(4-[5-(Cyclobutylmethoxy)-1-ethyl-1H-benzimidazol-6...)
Show SMILES CCn1cnc2cc(OCC3CCC3)c(cc12)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H21FN4O2/c20-13-3-1-2-12(10-13)6-7-21-18-19-23-11-15(24(19)9-8-22-18)14-4-5-16(25)17(14)26/h1-3,8-11,14,16-17,25-26H,4-7H2,(H,21,22)/t14-,16+,17-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9737516 (2017)

More data for this
Ligand-Target Pair