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Found 5 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50212128'
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of chemotaxis in human MCP1 monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50:  2.04nMAssay Description:Inhibition of Ca2+ flux in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at human CCR2b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50:  3.90nMAssay Description:Displacement of [125I]MCP1 from human CCR2 I40L mutant expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125I]MCP1 from mouse CCR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed