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Found 1 hit Enz. Inhib. hit(s) with Target = 'Carbonic Anhydrase II Mutant (F131V)' and Ligand = 'BDBM12018'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12018
PNG
(2,5-difluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,5-DIFLU...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1cc(F)ccc1F
Show InChI InChI=1S/C14H12F2N2O3S/c15-11-3-6-13(16)10(7-11)8-18-14(19)9-1-4-12(5-2-9)22(17,20)21/h1-7H,8H2,(H,18,19)(H2,17,20,21)
PDB
MMDB

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PC cid
PC sid
PDB
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Similars

AffyNet 
PDB
PubMed
n/an/an/a 2.20n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)