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Found 1 hit Enz. Inhib. hit(s) with Target = 'Carbonic Anhydrase II Mutant (F131V)' and Ligand = 'BDBM12023'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12023
PNG
(2,3,4,5,6-pentafluoro-SBB | 4-(AMINOSULFONYL)-N-[(...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C14H9F5N2O3S/c15-9-8(10(16)12(18)13(19)11(9)17)5-21-14(22)6-1-3-7(4-2-6)25(20,23)24/h1-4H,5H2,(H,21,22)(H2,20,23,24)
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PC cid
PC sid
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PubMed
n/an/an/a 2n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)