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Found 4 Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 9' and Ligand = 'BDBM25901'
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKi:  36nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKi:  3.60E+4nM ΔG°:  -25.4kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  430nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM25901(4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-...)
Affinity DataKd:  2nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (1 to 260 residues) expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissoci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed