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Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor IX' and Ligand = 'BDBM241370'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor IX


(Homo sapiens (Human))
BDBM241370
PNG
(US9409908, 2)
Show SMILES COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@H](N3CCC(=CC3=O)c3c(C)ccc(Cl)c3F)c3cc-2ccn3)c1
Show InChI InChI=1S/C32H32ClFN4O4/c1-18-7-10-24(33)30(34)29(18)21-12-14-38(28(39)16-21)27-6-4-5-19(2)31(40)37-25-17-22(36-32(41)42-3)8-9-23(25)20-11-13-35-26(27)15-20/h7-11,13,15-17,19,27H,4-6,12,14H2,1-3H3,(H,36,41)(H,37,40)/t19-,27+/m1/s1
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PC cid
PC sid
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US Patent
0.230n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...


US Patent US9409908 (2016)


BindingDB Entry DOI: 10.7270/Q27943K8
More data for this
Ligand-Target Pair