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Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor IX' and Ligand = 'BDBM241451'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor IX


(Homo sapiens (Human))
BDBM241451
PNG
(US9409908, 83)
Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2cc3c(C(O)=O)c(C)[nH]c3cc2NC1=O
Show InChI InChI=1S/C33H29ClF2N4O4/c1-16-4-3-5-27(40-11-9-19(13-28(40)41)30-23(35)7-6-22(34)31(30)36)26-12-18(8-10-37-26)20-14-21-25(15-24(20)39-32(16)42)38-17(2)29(21)33(43)44/h6-8,10,12-16,27,38H,3-5,9,11H2,1-2H3,(H,39,42)(H,43,44)/t16-,27+/m1/s1
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PC cid
PC sid
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US Patent
0.0600n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...


US Patent US9409908 (2016)


BindingDB Entry DOI: 10.7270/Q27943K8
More data for this
Ligand-Target Pair