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Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor IX' and Ligand = 'BDBM241528'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor IX


(Homo sapiens (Human))
BDBM241528
PNG
(US9409908, 160)
Show SMILES COC(=O)Nc1ccc2-c3nc([nH]c3C)[C@H](CCC[C@@H](C)C(=O)Nc2c1)N1CCC(=CC1=O)c1c(F)ccc(Cl)c1F
Show InChI InChI=1S/C30H30ClF2N5O4/c1-15-5-4-6-23(38-12-11-17(13-24(38)39)25-21(32)10-9-20(31)26(25)33)28-34-16(2)27(37-28)19-8-7-18(35-30(41)42-3)14-22(19)36-29(15)40/h7-10,13-15,23H,4-6,11-12H2,1-3H3,(H,34,37)(H,35,41)(H,36,40)/t15-,23+/m1/s1
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PC cid
PC sid
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US Patent
0.200n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...


US Patent US9409908 (2016)


BindingDB Entry DOI: 10.7270/Q27943K8
More data for this
Ligand-Target Pair