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Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor IX' and Ligand = 'BDBM241535'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor IX


(Homo sapiens (Human))
BDBM241535
PNG
(US9409908, 167)
Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)c(Cl)ccc2Br)c2cccc(c2)-c2cc(ccc2NC1=O)C(O)=O
Show InChI InChI=1S/C31H27BrClFN2O4/c1-17-4-2-7-26(36-13-12-20(16-27(36)37)28-23(32)9-10-24(33)29(28)34)19-6-3-5-18(14-19)22-15-21(31(39)40)8-11-25(22)35-30(17)38/h3,5-6,8-11,14-17,26H,2,4,7,12-13H2,1H3,(H,35,38)(H,39,40)/t17-,26+/m1/s1
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PC cid
PC sid
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US Patent
0.810n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...


US Patent US9409908 (2016)


BindingDB Entry DOI: 10.7270/Q27943K8
More data for this
Ligand-Target Pair