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Found 3 Enz. Inhib. hit(s) with Target = 'Coagulation factor XI' and Ligand = 'BDBM50011525'
TargetCoagulation factor XI(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50011525(CHEMBL2396787)
Affinity DataIC50:  820nMAssay Description:Inhibition of full-length human factor-11a-mediated S-2366 hydrolysis preincubated for 10 mins followed by substrate addition by spectrophotometric a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50011525(CHEMBL2396787)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of human factor-11a catalytic domain-mediated S-2366 hydrolysis preincubated for 10 mins followed by substrate addition by spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50011525(CHEMBL2396787)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to fluorescein-EGR-labeled human factor-11a by fluorescence spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed