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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM159157'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM159157
PNG
(US10093663, Example 5-4 | US9682968, Example-5-4)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H27N3O2S/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-25-12-4-3-5-21(25)17-6-8-18(9-7-17)28(23,26)27/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H2,23,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159157
PNG
(US10093663, Example 5-4 | US9682968, Example-5-4)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H27N3O2S/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-25-12-4-3-5-21(25)17-6-8-18(9-7-17)28(23,26)27/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H2,23,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair