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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM159312'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM159312
PNG
(US10093663, Example 17-1 | US9682968, Example-17-1)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-16-14-21(17-5-6-17)22(20-11-12-26-24(16)20)15-27-13-3-2-4-23(27)18-7-9-19(10-8-18)25(28)29/h7-12,14,17,23,26H,2-6,13,15H2,1H3,(H,28,29)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159312
PNG
(US10093663, Example 17-1 | US9682968, Example-17-1)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-16-14-21(17-5-6-17)22(20-11-12-26-24(16)20)15-27-13-3-2-4-23(27)18-7-9-19(10-8-18)25(28)29/h7-12,14,17,23,26H,2-6,13,15H2,1H3,(H,28,29)/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair