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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM160036'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM160036
PNG
(US10093663, Example 21a | US9682968, Example-21a)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-8-10-25-23(15)19)14-26-11-9-18(29-2)13-21(26)16-4-6-17(7-5-16)24(27)28/h4-8,10,12,18,21,25H,9,11,13-14H2,1-3H3,(H,27,28)/t18-,21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160036
PNG
(US10093663, Example 21a | US9682968, Example-21a)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-8-10-25-23(15)19)14-26-11-9-18(29-2)13-21(26)16-4-6-17(7-5-16)24(27)28/h4-8,10,12,18,21,25H,9,11,13-14H2,1-3H3,(H,27,28)/t18-,21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair