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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM160500'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM160500
PNG
(US10093663, Example 37 | US9682968, Example-37)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C26H33N3O5S/c1-5-34-20-11-13-29(16-22-21-10-12-27-25(21)17(2)14-24(22)33-3)23(15-20)18-6-8-19(9-7-18)26(30)28-35(4,31)32/h6-10,12,14,20,23,27H,5,11,13,15-16H2,1-4H3,(H,28,30)/t20-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160500
PNG
(US10093663, Example 37 | US9682968, Example-37)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C26H33N3O5S/c1-5-34-20-11-13-29(16-22-21-10-12-27-25(21)17(2)14-24(22)33-3)23(15-20)18-6-8-19(9-7-18)26(30)28-35(4,31)32/h6-10,12,14,20,23,27H,5,11,13,15-16H2,1-4H3,(H,28,30)/t20-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair