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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM160505'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM160505
PNG
(US10093663, Example 39-4 | US9682968, Example-39-4)
Show SMILES COCCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC
Show InChI InChI=1S/C27H35N3O4/c1-18-15-25(34-4)23(22-9-11-28-26(18)22)17-30-13-10-21(33-3)16-24(30)19-5-7-20(8-6-19)27(31)29-12-14-32-2/h5-9,11,15,21,24,28H,10,12-14,16-17H2,1-4H3,(H,29,31)/t21-,24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160505
PNG
(US10093663, Example 39-4 | US9682968, Example-39-4)
Show SMILES COCCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC
Show InChI InChI=1S/C27H35N3O4/c1-18-15-25(34-4)23(22-9-11-28-26(18)22)17-30-13-10-21(33-3)16-24(30)19-5-7-20(8-6-19)27(31)29-12-14-32-2/h5-9,11,15,21,24,28H,10,12-14,16-17H2,1-4H3,(H,29,31)/t21-,24-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair