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Found 3 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 7' and Ligand = 'BDBM50358213'
TargetCyclin-dependent kinase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50358213(CHEMBL1922219 | US8846696, (2R3S)-3-{9-Isopropyl-6...)
Affinity DataIC50:  520nMAssay Description:Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50358213(CHEMBL1922219 | US8846696, (2R3S)-3-{9-Isopropyl-6...)
Affinity DataIC50:  1.30E+3nMpH: 7.4Assay Description:The compounds from the examples below were investigated for their CDK2/cyclin E, CDK1/cyclin B, CDK4/cyclin D1 and CDK7/cyclin H, ERK-2, and PKA inhi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50358213(CHEMBL1922219 | US8846696, (2R3S)-3-{9-Isopropyl-6...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed