Found 6 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 8' and Ligand = 'BDBM50191357' 
Affinity DataIC50: 3nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 6.5nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK8 in human COLO205 cells expressing APC mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of CDK8 in human LS174T cells expressing beta-catenin mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of CDK8 in human PA1 cells assessed as suppression of WNT3a ligand-induced WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
