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Found 2 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 11B2 (CYP11B2)' and Ligand = 'BDBM336856'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM336856
PNG
(US9745289, Compound 16A | US9745289, Compound 16B)
Show SMILES NC(=O)c1cccc2OC(COc12)c1cncc(c1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H17N3O5S/c21-20(24)16-2-1-3-17-19(16)27-11-18(28-17)14-8-13(9-23-10-14)12-4-6-15(7-5-12)29(22,25)26/h1-10,18H,11H2,(H2,21,24)(H2,22,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assays are performed in 96-well format in a final volume of 60 μL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additi...


US Patent US9745289 (2017)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM336856
PNG
(US9745289, Compound 16A | US9745289, Compound 16B)
Show SMILES NC(=O)c1cccc2OC(COc12)c1cncc(c1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H17N3O5S/c21-20(24)16-2-1-3-17-19(16)27-11-18(28-17)14-8-13(9-23-10-14)12-4-6-15(7-5-12)29(22,25)26/h1-10,18H,11H2,(H2,21,24)(H2,22,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assays are performed in 96-well format in a final volume of 60 μL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additi...


US Patent US9745289 (2017)

More data for this
Ligand-Target Pair