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Found 5 Enz. Inhib. hit(s) with Target = 'D-amino-acid oxidase' and Ligand = 'BDBM31156'
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)
Affinity DataIC50:  4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)
Affinity DataIC50:  40nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)
Affinity DataKd:  7nMAssay Description:Binding affinity to human recombinant DAAO by steady state study scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31156(3-hydroxyquinolin-2(1H)-one, 10)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed