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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50049904'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Homo sapiens (Human))
BDBM50049904
PNG
(7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL3...)
Show SMILES Nc1nc(N)c2c3cc[nH]c3ccc2n1
Show InChI InChI=1S/C10H9N5/c11-9-8-5-3-4-13-6(5)1-2-7(8)14-10(12)15-9/h1-4,13H,(H4,11,12,14,15)
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem

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Similars

Article
PubMed
1n/an/an/an/an/an/an/an/a



Oregon Health& Science University

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolate


Medchemcomm 6: 510-520 (2015)


Article DOI: 10.1039/c4md00485j
BindingDB Entry DOI: 10.7270/Q2QN68NS
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (Human))
BDBM50049904
PNG
(7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL3...)
Show SMILES Nc1nc(N)c2c3cc[nH]c3ccc2n1
Show InChI InChI=1S/C10H9N5/c11-9-8-5-3-4-13-6(5)1-2-7(8)14-10(12)15-9/h1-4,13H,(H4,11,12,14,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Dihydrofolate reductase enzyme


J Med Chem 39: 892-903 (1996)


Article DOI: 10.1021/jm9505122
BindingDB Entry DOI: 10.7270/Q2XD10RC
More data for this
Ligand-Target Pair