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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 4' and Ligand = 'BDBM150238'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM150238
PNG
(US8980929, Example Compound 6)
Show SMILES N[C@H]1C[C@H](CCO[C@@H]1c1cc(F)ccc1F)N1Cc2cn(nc2C1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C20H24F2N4O3S/c21-13-1-4-17(22)16(7-13)20-18(23)8-14(5-6-29-20)25-9-12-10-26(24-19(12)11-25)30(27,28)15-2-3-15/h1,4,7,10,14-15,18,20H,2-3,5-6,8-9,11,23H2/t14-,18-,20+/m0/s1
PDB
MMDB

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PC cid
PC sid
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Similars

US Patent
n/an/a 5.80n/an/an/an/a7.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...


US Patent US8980929 (2015)


BindingDB Entry DOI: 10.7270/Q2MK6BMJ
More data for this
Ligand-Target Pair