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Found 2 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM31275'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Max Planck Institute

LigandPNGBDBM31275(Chalcone derivative, B-1)
Affinity DataIC50:  1.17E+5nMpH: 7.4 T: 2°CAssay Description:Interference of the p53-MDM2 binding by test compounds was measured in a 96-well polypropylene round-bottom microtiter plate (Costar, Serocluster). H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Max Planck Institute

LigandPNGBDBM31275(Chalcone derivative, B-1)
Affinity DataKd:  1.50E+5nMpH: 7.4 T: 2°CAssay Description:NMR measurements consisted of monitoring changes in chemical shifts and line widths of the backbone amide resonances of uniformly 15N-enriched MDM2 s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed