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Found 3 Enz. Inhib. hit(s) with Target = 'Endothelial PAS domain-containing protein 1' and Ligand = 'BDBM373000'
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM373000(US10597366, Compound 124 | US9896418, Compound 124)
Affinity DataIC50:  38nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM373000(US10597366, Compound 124 | US9896418, Compound 124)
Affinity DataIC50:  220nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM373000(US10597366, Compound 124 | US9896418, Compound 124)
Affinity DataEC50:  240nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed