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Found 10 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM149410'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  5.5nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  5.5nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  5.5nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  5.5nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  132nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  200nMAssay Description:Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM149410(US10434101, Compound I-10 | US11096942, Compound I...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed