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Found 12 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM373725'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  9nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  51nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  125nMAssay Description:Inhibition of probe binding to wild type EGFR (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  204nMAssay Description:Inhibition of EGFR ex19del mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50:  550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under partial equilibrat...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under full equilibrating...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataKd:  16nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under predilution/full e...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373725(US10246444, Example 98)
Affinity DataKd:  8.40nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under equilibrate/3-fold...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed