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Found 8 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM4566'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGF-induced autophosphorylation of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataEC50:  50nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed