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Found 2 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E' and Ligand = 'BDBM50386763'
TargetEukaryotic translation initiation factor 4E(Oryctolagus cuniculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50386763(CHEMBL2046902)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50386763(CHEMBL2046902)
Affinity DataIC50:  4.93E+4nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed