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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM339848'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM339848
PNG
(US9757364, Compound 47)
Show SMILES COc1cc(OC)cc(c1)N(Cc1nnc[nH]1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N8O2/c1-30-12-16(11-27-30)15-6-21-20(24-10-15)4-5-23(28-21)31(13-22-25-14-26-29-22)17-7-18(32-2)9-19(8-17)33-3/h4-12,14H,13H2,1-3H3,(H,25,26,29)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 0.692n/an/an/an/an/an/a



ASTEX THERAPEUTICS LTD

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9757364 (2017)


Article DOI: 10.1074/jbc.M512374200
More data for this
Ligand-Target Pair