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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 6' and Ligand = 'BDBM191004'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0274n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.74E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.74E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair