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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 6' and Ligand = 'BDBM191019'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191019
PNG
(US10077266, Example 131 | US9181249, 131 | US97083...)
Show SMILES CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H31F2N5O2/c1-4-22(32)31-12-9-19-20(14-31)28-23(27-15(2)3)24(29-19)30-10-7-17(8-11-30)33-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,4,7-12,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0276n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191019
PNG
(US10077266, Example 131 | US9181249, 131 | US97083...)
Show SMILES CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H31F2N5O2/c1-4-22(32)31-12-9-19-20(14-31)28-23(27-15(2)3)24(29-19)30-10-7-17(8-11-30)33-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,4,7-12,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.76E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191019
PNG
(US10077266, Example 131 | US9181249, 131 | US97083...)
Show SMILES CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1
Show InChI InChI=1S/C24H31F2N5O2/c1-4-22(32)31-12-9-19-20(14-31)28-23(27-15(2)3)24(29-19)30-10-7-17(8-11-30)33-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,4,7-12,14H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.76E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair