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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 6' and Ligand = 'BDBM191022'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191022
PNG
(US10077266, Example 134 | US9181249, 134 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O
Show InChI InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0270n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191022
PNG
(US10077266, Example 134 | US9181249, 134 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O
Show InChI InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191022
PNG
(US10077266, Example 134 | US9181249, 134 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O
Show InChI InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair