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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 6' and Ligand = 'BDBM382124'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382124
PNG
(6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopr...)
Show SMILES COCc1nc(NC(C)C)c(nc1C#N)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F2N5O2/c1-13(2)25-20-21(27-17(11-24)18(26-20)12-29-3)28-8-6-15(7-9-28)30-19-5-4-14(22)10-16(19)23/h4-5,10,13,15H,6-9,12H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.37E+4n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10273225 (2019)


BindingDB Entry DOI: 10.7270/Q24X5B3J
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382124
PNG
(6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopr...)
Show SMILES COCc1nc(NC(C)C)c(nc1C#N)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F2N5O2/c1-13(2)25-20-21(27-17(11-24)18(26-20)12-29-3)28-8-6-15(7-9-28)30-19-5-4-14(22)10-16(19)23/h4-5,10,13,15H,6-9,12H2,1-3H3,(H,25,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.37E+4n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10000468 (2018)


BindingDB Entry DOI: 10.7270/Q23R0W71
More data for this
Ligand-Target Pair