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Found 4 Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50075749'
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075749(4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-py...)
Affinity DataIC50:  17nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075749(4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-py...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of rat brain cytosol farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075749(4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-py...)
Affinity DataIC50:  270nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075749(4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-py...)
Affinity DataIC50:  4.74E+3nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article