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Found 6 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50172022'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataIC50:  3.16nMAssay Description:Binding affinity to human recombinant glucocorticoid receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataIC50:  4nMAssay Description:Binding affinity towards glucocorticoid receptor using fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataIC50:  10nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced coll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataIC50:  50.1nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-8...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataEC50:  10nMAssay Description:Effective agonist concentration for transcriptional repression of IL-6 production in IL-1 stimulated human foreskin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bayer Schering Pharma

Curated by ChEMBL
LigandPNGBDBM50172022(4-(5-Fluoro-2-hydroxy-phenyl)-2-hydroxy-4-methyl-2...)
Affinity DataEC50:  25.1nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells assessed as induction of MMTV promoter activity by luciferase reporter gene a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed