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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM267429'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM267429
PNG
(US9718822, 16)
Show SMILES Fc1cnc2OCCONC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1
Show InChI InChI=1S/C18H17FN6O3/c19-11-8-12-14-2-1-4-24(14)15-3-5-25-16(22-15)13(10-21-25)17(26)23-28-7-6-27-18(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2,(H,23,26)/t14-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/a7.5n/a



Array BioPharma, Inc.

US Patent


Assay Description
The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen¿ Eu Kinase Binding Assay. In this assay, His-tagged recombina...


US Patent US9718822 (2017)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM267429
PNG
(US9718822, 16)
Show SMILES Fc1cnc2OCCONC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1
Show InChI InChI=1S/C18H17FN6O3/c19-11-8-12-14-2-1-4-24(14)15-3-5-25-16(22-15)13(10-21-25)17(26)23-28-7-6-27-18(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2,(H,23,26)/t14-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/a7.5n/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9718822 (2017)

More data for this
Ligand-Target Pair